Issue: 2010, Vol. 15, No. 1

Laryushkina Р.М., Ryvkin А.И., Pobedinskaya Н.С., Reshetova Т.Г., Sokolova Т.Б., Filina И.В.

SYSTEMIC ANALYSIS OF CHANGES OF PHOSPHOLIPID COMPONENTS OF LUNG SURFACTANT AND THEIR CORRECTION IN ATOPIC BRONCHIAL ASTHMA IN CHILDREN

Keywords

bronchial asthma, lung surfactant, lung respiratory function

Abstarct

Functional state of lung surfactant system by the parameters of phospholipid spectrum of the expired air condensate and blood serum were examined in 113 children with atopic bronchial asthma. It was stated that the bronchial asthma development was accompanied by phase changes of superficial active properties of lung alveolar cover. They were determined by the activity of the inflammatory process, remoteness and peculiarity of the disease course. It was revealed that the changes of phospholipid markers were coupled with the parameter alterations of lung respiratory function (lung moisture excretion, mucociliary clearance, bronchi daily lability, external inspiration). This finding disclosed one of the possible pathogenic mechanisms of prolonged chronic allergic inflammation and was the predisposition to the development of scientifically based methods of surfactantprotective correction in children with atopic bronchial asthma.